• Ketone bodies are “the killers” being responsible for all subsequent negative effects (oxidative stress/ oxygen radicals)

  • Early detection and interference are key to prevent clinical effects and economical losses caused by ketone bodies! Go and check your dry cows’ feed intake and BCS on regular scale

  • Undetected subclinical ketosis can also lead to cellular damages, immunosuppression and in consequence increased incidence of secondary diseases e.g. mastitis, metritis and ketosis Go and check regularly blood BHBA levels of your fresh cows!

  • Did you ever wonder about your poor first service conception rates? SCK could be one of the causes you can fix to improve reproductive outcome.

  • Did you already know? Latest investigations reveal a strong correlation between excessive loss of BCS and increased risk of lameness. Go for our updated BCS Cowdition App to get in control of your herd.

  • Negative impact of (subclinical) ketosis on milk yields and subsequent diseases still seems to be underestimated Take your time to make a cost-benefit calculation

Limitation of lipomobilization

  • Stress reduction / cow comfort
  • B vitamins (niacin, cyanocobalamin)
  • Genetic predisposition of milk lipid synthesis
  • Rumen-protected fatty acids

Lipomobilization is promoted primarily by stress (adrenaline) and a high glucagon:insulin ratio 15. Stress reduction is an underestimated measure for limiting lipomobilization.

Insulin applications can likewise limit lipomobilization through a reduction of the glucagon:insulin ratio. The administration of insulin is not approved in every country, however, and also carries the risk of even worse glucose availability for the tissues.

B vitamins can also be used for the prevention and therapy of ketosis:

  • Niacin has an anti-lipolytic activity and positive effects in the rumen 19
  • Cyanocobalamin and biotin are involved in the metabolism of propionate for gluconeogenesis via succinate and the tricarboxylic acid cycle (TCA)

Certain cows are able to synthesize milk lipids particularly effectively from blood plasma lipids and show a significantly lower prevalence of ketosis. Such cows can be recognized via a high content of glycerophosphocholine in the milk, which may open up the possibility of breeding selection for ketosis resistance 68.

Insulin limits lipomobilization hormonally. Without simultaneous glucose infusion for stabilization of glucose metabolism, however, therapeutic insulin administration is contraindicated. In some countries administration of insulin to cows is not permitted.

  • Far-off/close-up feeding
  • Stress reduction
  • Cow comfort
  • Insulin (dangerous side-effects, banned in some markets, only with concomitant glucose infusion)

* see also our references page